Comparing Subanesthetic Propofol and Single-Dose Dexmedetomidine to Prevent Emergence Agitation in Adults Undergoing Rhinoplasty

What this Trial Is About

Researchers are evaluating ways to prevent emergence agitation, a common complication after rhinoplasty surgery, by comparing two medications subanesthetic propofol and a single dose of dexmedetomidine. This interventional study uses a double-blind design involving 80 patients aged 18 to 65 years who are classified as ASA I-II. The study aims to determine which medication better reduces agitation after anesthesia. Participants will be randomly assigned to one of two groups. Both groups will receive standard general anesthesia with drugs including midazolam, fentanyl, propofol, and rocuronium, along with maintenance anesthesia using sevoflurane. One group will receive a 0.5 mcgkg dexmedetomidine infusion over 10 minutes after nasal packing, while the other group will get a 0.5 mgkg propofol intravenous bolus at the same time. Postoperative pain relief will use paracetamol and tramadol before surgery ends, and muscle relaxation will be reversed with sugammadex. During the study, patients will be closely monitored for agitation using the Richmond Agitation Sedation Scale one minute after extubation. Heart rate, blood pressure, and oxygen saturation will be tracked at various times before, during, and after surgery. Additional observations will include any involuntary movements, laryngospasm, nausea, vomiting, or low oxygen levels after extubation. Recovery time will also be recorded. All collected data will be analyzed to compare the effects of the two medications on emergence agitation.

Prevention of Emergence Agitation in Rhinoplasty With Subanesthetic Propofol and Single-Dose Dexmedetomidine: A Prospective Double-Blind Clinical Study