Actively Recruiting
Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
Led by Vejle Hospital · Updated on 2026-04-03
120
Participants Needed
1
Research Sites
228 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.
CONDITIONS
Official Title
Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathologically verified adenocarcinoma of the colon or rectum and planned standard adjuvant treatment with capecitabine in combination with oxaliplatin.
- ECOG performance status 0-2.
- Written and orally informed informed consent.
You will not qualify if you...
- Inability to speak, read, and understand Danish.
- Previous treatment with neurotoxic chemotherapy.
- Neurological (including neuropathy) or psychiatric disorders, diabetes or other significant medical conditions.
- Alcohol or drug abuse.
- Sensory disturbances in the feet.
- Spinal stenosis.
- Vascular disease (Fontaine grade II or more).
- Known allergy to fish, fish oil or corn oil.
- Fertile patients not willing to use effective methods of contraception during treatment or abstinence.
- Daily intake of oil supplements and not willing to stop during the trial period.
- Lack of consent to skin biopsy.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Deparment of Oncology, Vejle Hospital
Vejle, Denmark
Actively Recruiting
Research Team
N
Nina Lykkegaard Gehr, MD.
CONTACT
K
Karin Larsen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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