Actively Recruiting
Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-10-28
60
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectives of this study are to determine the feasibility of conducting a full-scale randomized control trial comparing the efficacy of tamsulosin compared to placebo in reducing post-operative urinary retention in people undergoing elective thoracic surgery.
CONDITIONS
Official Title
Prevention of Post Operative Urinary Retention After Thoracic Surgery Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have two or more of the following risk factors: male sex, age 40 years or older, history of diabetes mellitus, prior pelvic irradiation, use of indwelling thoracic epidural analgesia, or prior history of urinary retention
- Have an International Prostate Specific Score of 1 or higher
You will not qualify if you...
- Currently being treated for Benign Prostatic Hyperplasia (BPH)
- Allergic or hypersensitive to tamsulosin hydrochloride
- Currently taking tamsulosin or another alpha-blocker, or used one within 3 weeks before enrollment
- Have an active urinary tract infection
- History of specific urological disorders such as urethral stricture, BPH, bladder or prostate cancer
- History of urological surgeries including prostate or bladder surgeries
- Have neurological disorders affecting bladder function
- Known contraindications to tamsulosin hydrochloride
- Are nursing or breastfeeding women
- Use of intraoperative bladder catheter
- Scheduled for cataract and/or glaucoma surgery
- Taking strong or moderate inhibitors of CYP3A4 or CYP2D6 enzymes or are CYP2D6 poor metabolizers
- Have a serious or life-threatening sulfa allergy
- Have severe liver problems
- Have severe kidney problems with creatinine clearance under 10 mL/min
AI-Screening
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Trial Site Locations
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
D
Deb Lewis
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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