Actively Recruiting
Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment
Led by Stanford University · Updated on 2026-02-17
600
Participants Needed
1
Research Sites
1765 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible AF will be randomized to prophylactic amiodarone treatment versus no treatment. Patients who are not inducible to AF will be treated with standard post-operative care. Patients will be monitored post-operatively to explore the value of intraoperative inducibility of AF to predict POAF and to evaluate whether the combination of intraoperative inducibility and precision amiodarone therapy is effective at reducing the incidence of POAF
CONDITIONS
Official Title
Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled for first-time non-emergent open-heart surgery including coronary artery bypass graft, valve repair or replacement, combined CABG with valve repair or replacement, or valve sparing aortic root repair
- Normal sinus rhythm
- No documented history of atrial fibrillation
You will not qualify if you...
- Prior heart surgery involving cardiopulmonary bypass
- Any prior documented atrial fibrillation, atrial flutter, or atrial tachycardia lasting more than 30 seconds
- Previous treatment with amiodarone for supraventricular tachy-arrhythmias
- Need for surgical treatment of atrial arrhythmias such as pulmonary vein isolation or Maze procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
A
Anson Lee, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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