Circadian Strain, Light Exposure, and Depressive Symptoms in Rural Communities of Southern Brazil.
Luísa K Pilz, Nicóli B Xavier, Rosa Levandovski...
https://pubmed.ncbi.nlm.nih.gov/36925579/Actively Recruiting
Led by Hospital de Clinicas de Porto Alegre · Updated on 2025-12-03
150
Participants Needed
1
Research Sites
N/A
Total Duration
Depression and anxiety during pregnancy and the postnatal period are major health concerns, especially in developing countries. These mental health issues have been linked to disruptions in biological rhythms, sleep problems, and low daylight exposure. This research aims to evaluate the effectiveness of Blue Light Therapy BlueLT for reducing depressive and anxiety symptoms in women with postpartum depression. The study also explores how alignment between rest-activity rhythms and internal body clock may influence treatment effects. Women with postpartum depression will be randomly assigned to use either the BlueLT device, which emits short-wavelength blue light, or a placebo device called ControlLT that emits dim, long-wavelength light. Both groups will use their assigned light therapy for 30 minutes daily before 4 p.m. for 30 consecutive days. Additionally, a healthy control group of women without depressive symptoms will be included to compare natural circadian changes unrelated to depression or treatment. Participants will be involved for about one month, during which their depressive and anxiety symptoms will be assessed from enrollment to the end of treatment. Researchers will also monitor rest-activity rhythms, light exposure, temperature rhythms, sleep patterns, social jetlag, and internal body time using a blood sample. Safety and health of both mothers and newborns will be observed, ensuring no interference from medical conditions or newborn health issues.
CONDITIONS
From Prevention to Treatment: How Biological Rhythms Can Maintain Perinatal Mental Health
M
Maria Paz L Hidalgo
G
Guilherme R Amando
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Hospital de Clinicas de Porto Alegre
Lead Sponsor
Federal University of Rio Grande do Sul
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 30 days
Participants with postpartum depression use the assigned light therapy device daily for 30 minutes before 4 p.m. for 30 consecutive days to reduce depressive and anxiety symptoms.
Daily light therapy use with scheduled visits for assessments during treatment
Duration - Up to 4 weeks post-treatment
Participants are monitored after completing the treatment to assess ongoing effects on mood and biological rhythms.
1 to 2 visits depending on assessment schedule
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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https://pubmed.ncbi.nlm.nih.gov/35670313/Hospital de Clinicas de Porto Alegre
Lead Sponsor
Federal University of Rio Grande do Sul
Collaborating Sponsor