Actively Recruiting
PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS
Led by Democritus University of Thrace · Updated on 2024-10-08
250
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients hospitalized for acute decompensation of CHF are usually complicated by worsening renal function (WRF) which leads to diuretic resistance and inadequate decongestion as well as poor prognosis. WRF has been attributed to a reflex renal vasoconstriction elicited by intravascular volume depletion during brisk diuresis. The investigators hypothesize that CHF patients with hepatic dysfunction are more prone to WRF due to poor albumin production. This sub-group of CHF patients may benefit more (increased diuretic efficacy and protected against worsening renal function) by the use of IV loop diuretics in combination with an intravascular volume expander such as IV Human Albumin.
CONDITIONS
Official Title
PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Acute worsening of chronic heart failure
- Liver dysfunction confirmed by lab tests or liver ultrasound
- History of chronic heart failure with prior use of oral loop diuretics
- Expected need for intravenous diuretic therapy for at least 72 hours
You will not qualify if you...
- Hemodynamic collapse defined by very low blood pressure or need for heart support medications (except digoxin)
- Liver dysfunction caused by conditions other than heart failure
- Severe anemia with hemoglobin less than 8 g/dL
- Uncontrolled high blood pressure or hypertensive emergency
- Pulmonary edema or congestion requiring intravenous vasodilators
- Serum creatinine over 3 mg/dL or kidney filtration rate less than 30 ml/min
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
DUThrace Cardiology Department
Alexandroupoli, Evros, Greece, 68100
Actively Recruiting
Research Team
M
MARIOS-VASILEIOS A KOUTROULOS
CONTACT
A
ANARGYROS TSALGKIDIS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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