Actively Recruiting
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
Led by Yonsei University · Updated on 2026-01-05
450
Participants Needed
8
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period. The purpose of this study to compare the clinical outcomes of Left Bundle Branch Area Pacing (LBBAP) compared to Right Ventricular Pacing (RVP) in bradyarrhythmia patients who require high burden of ventricular pacing (\>40%).
CONDITIONS
Official Title
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 19 years old and able to give informed consent
- Willing and able to comply with follow-up tests and evaluation schedules
- Scheduled to receive a pacemaker implant
- Expected to require substantial ventricular pacing (>40%)
You will not qualify if you...
- Incapacitated or unable to read or write
- Indicated for implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT)
- History of prosthetic valve surgery on the tricuspid valve
- Prior myocardial infarction including ventricular septum
- Life expectancy less than 12 months due to any condition
- Unavailable for at least 24 months of follow-up visits
- Pregnant or breastfeeding at the time of consent
- Prior heart transplant surgery
- Persistent Left Superior Vena Cava (PLSVC)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Bucheon Sejong Hospital
Bucheon-si, South Korea
Actively Recruiting
2
GyeongSang National University Changwon Hospital
Changwon, South Korea
Actively Recruiting
3
Chungbuk National University Hospital
Chungju, South Korea
Actively Recruiting
4
Asan Medical Center
Seoul, South Korea
Actively Recruiting
5
Kyunghee University hospital
Seoul, South Korea
Actively Recruiting
6
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
7
Seoul Saint Mary's Hospital
Seoul, South Korea
Actively Recruiting
8
Yonsei University Health System, Severance Hospital
Seoul, South Korea
Not Yet Recruiting
Research Team
T
TaeHoon Kim
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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