Study to Test Fractionated Laser Resurfacing for Preventing Precancerous and Cancerous Skin Changes in Older Adults with Actinic Keratoses

What this Trial Is About

Researchers are evaluating the preventive effects of Fractionated Laser Resurfacing FLR on precancerous actinic keratosis AKs and skin cancer in older adults with active AKs. This study aims to see if FLR can protect one forearm or wrist from developing AKs and non-melanoma skin cancers. Additionally, it tests whether skin photographs can predict where these lesions and cancers will appear. The study focuses on an at-risk geriatric population with fair skin. Participants receive FLR treatment on either the right or left forearmwrist. FLR is a device that creates tiny holes in the superficial skin layers, intended to rejuvenate the skin. The trial is randomized and compares the outcomes between the treated arms. Follow-up lasts up to five years to monitor changes in the number of AKs and non-melanoma skin cancers as well as skin dysplasia. During the study, participants will be regularly assessed for changes in their skin condition, including the number of AKs and skin cancers. Researchers will use photography and clinical evaluations to track these changes over time. Safety and treatment effects are monitored throughout the long-term follow-up, with the primary outcomes measured up to five years after treatment.

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population