Actively Recruiting
Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases.
Led by Menzies School of Health Research · Updated on 2026-03-12
100
Participants Needed
4
Research Sites
241 weeks
Total Duration
On this page
Sponsors
M
Menzies School of Health Research
Lead Sponsor
C
Curtin University
Collaborating Sponsor
AI-Summary
What this Trial Is About
A non randomized observation study that is aiming to assess the safety and efficacy of high dose primaquine (1mg/kg per day over 7 days) among patients with intermediate (30-70%) G6PD activity and the safety and efficacy of weekly primaquine among patients who are g6Pd deficient (\<30% activity)
CONDITIONS
Official Title
Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed Plasmodium vivax mono-infection
- G6PD enzyme activity between 30 and less than 70% or 30% or less of the adjusted male median as determined by Standard G6PD test
- Fever with temperature 37.5°C or higher or history of fever in the past 48 hours
- Age 18 years or older
- Hemoglobin level at presentation of 8 g/dl or higher
- Provided written informed consent
- Living in the study area and willing to be followed for six months
You will not qualify if you...
- Signs or symptoms of severe malaria
- Pregnant or breastfeeding women
- Regular use of drugs known to cause hemolysis
- Known allergy or hypersensitivity to any study drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Dr Marcus Lacerda
Manaus, Brazil
Actively Recruiting
2
Arba Minch General Hospital
Arba Minch, Ethiopia
Not Yet Recruiting
3
Dr Moses Laman and Dr Brioni Moore
Alexishafen, Madang Province, Papua New Guinea
Actively Recruiting
4
Papua New Guinea Institute of Medical Research
Port Moresby, Magang, Papua New Guinea
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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