Actively Recruiting
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Led by Weill Medical College of Cornell University · Updated on 2026-04-20
100
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
CONDITIONS
Official Title
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Diagnosed with mild cognitive impairment (MCI) or early stage probable or possible Alzheimer's disease
- Mild cognitive deficits with MoCA score between 16 and 25
- Montgomery Asberg Depression Rating Scale (MADRS) score of 5 or higher indicating mild depressive symptoms
- Stable or no use of antidepressants, cholinesterase inhibitors, or memantine for at least 12 weeks
- Chronic pain present most days for 3 months or longer with average pain intensity score of 4 or higher
- Clinical Dementia Rating (CDR) between 0.5 and 1
- Capacity to provide informed consent
- Have a study partner such as a caregiver or family member willing to participate
You will not qualify if you...
- Significant suicide risk as determined by the study team
- Medically or neurologically unstable for safe participation
- Psychiatrically unstable for randomized psychotherapy trial
- Currently requiring psychiatric hospitalization
- Not fluent in English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
White Plains, New York, United States, 10502
Actively Recruiting
Research Team
D
Dimtiris Kiosses, PhD
CONTACT
L
Laurie Evans, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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