Actively Recruiting
Psychosocial Therapy to Improve Memory, Depression, and Pain in Older Adults with Mild Cognitive Impairment or Early Alzheimers
Led by Weill Medical College of Cornell University · Updated on 2026-04-20
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of Problem Adaptation Therapy for Pain PATH-Pain on cognitive function, depression, and pain-related disability in older adults who have mild cognitive impairment or early stage Alzheimers disease, along with chronic pain and depression. The study compares PATH-Pain to Attention Control Usual Care to see which approach leads to better cognitive, emotional, and functional outcomes in this population. This is a randomized control trial with a focus on real-world application in primary care settings. Participants in the PATH-Pain group receive a total of 14 therapy sessions eight weekly in-office sessions during the first eight weeks, followed by six monthly phone sessions three individual and three group from weeks 9 to 36. The therapy teaches emotion regulation, problem-solving skills, and uses compensatory strategies to help manage memory challenges. A tablet app called WellPATH may be used to support emotion regulation techniques. The control group receives usual medical care from their physicians and additional structured interviews and educational sessions unrelated to cognitive impairment, pain, or depression, plus an educational booklet. During the study, participants undergo assessments at the start and at weeks 5, 9, 24, 36, and 52. These include tests of cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status, evaluations of depressive symptoms, and measures of pain-related disability. Each therapy session lasts about 50 minutes. Caregiver participation is required, and the study monitors cognitive changes, mood, and pain-related functional abilities over one year. The study aims to evaluate the overall impact of PATH-Pain compared to usual care in this group of older adults.
CONDITIONS
Brief Title
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Research Team
D
Dimtiris Kiosses, PhD
L
Laurie Evans, MS
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