Comparison of Fractional Flow Reserve and Myocardial Perfusion Imaging in Saphenous Vein Grafts.
Roel Hoek, Ruben W de Winter, Rens T Peters...
https://pubmed.ncbi.nlm.nih.gov/39991799Actively Recruiting
Age: 18Years - 90Years
All Genders
ID04772768
Patients With Prior Coronary Artery Bypass Graft Surgery Evaluated for Saphenous Vein Graft Dysfunction and Progression of Coronary Artery Disease
Led by Amsterdam UMC, location VUmc · Updated on 2023-06-02
500
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study patients who have had coronary artery bypass grafting (CABG) surgery and have at least one saphenous vein graft (SVG), especially those experiencing recurrent ischemic symptoms. The goal is to understand clinical outcomes related to graft failure and progression of native coronary artery disease (CAD). This observational study focuses on patients often older with complex heart conditions who are evaluated for these issues, as current treatment guidelines are limited for this group. Participants will be observed without intervention, with data collected from national registries, electronic medical records, and standardized phone assessments at 3 and 5 years after enrollment. Diagnostic results from non-invasive and invasive tests, such as graft patency and heart function assessments, will be gathered to evaluate their usefulness in guiding repeat revascularization treatments. During the study, participants will undergo regular follow-up assessments at 3 and 5 years to monitor major cardiovascular events and graft status. Quality of life will be measured using specific heart-related questionnaires. Researchers will also track procedural success and mortality for patients who undergo further interventions. The total observation period includes ongoing data collection through medical records and patient contact to better understand long-term outcomes after CABG.
CONDITIONS
Brief Title
Prior CABG Patients Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease
Who Can Participate
Age: 18Years - 90Years
All Genders
Eligibility Criteria
You may qualify if you...
- Prior coronary artery bypass grafting
- One or more saphenous vein grafts
- Recurrent angina symptoms
You will not qualify if you...
- Under 18 years of age
- Age 90 years or older
- Cardiogenic shock
- Pregnancy
- Failure to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - At the time of referral
Participants undergo clinical evaluation and diagnostic work-up to assess saphenous vein graft patency, native coronary artery disease progression, left ventricular function, and myocardial viability.
1 visit (in-person)
Long-term Monitoring
Duration - 3 to 5 years
Participants are observed over several years to track clinical outcomes including major adverse cardiovascular events and graft failure, with assessments of quality of life.
Follow-up visits at baseline and during 3 and 5 years
Trial Site Locations
Total: 1 location
1
Amsterdam University Medical Centers, Department of Cardiology
Amsterdam, Netherlands, 1081 HV
Actively Recruiting
Loading map...
Research Team
P
Paul Knaapen, Professor
R
Ruben de Winter, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here