Actively Recruiting
Probenecid Administration for Alcohol Craving and Consumption
Led by Brown University · Updated on 2026-03-17
120
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
CONDITIONS
Official Title
Probenecid Administration for Alcohol Craving and Consumption
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, 18 years or older
- Women who drink more than 7 drinks per week; men who drink more than 14 drinks per week
- Meet moderate to severe Alcohol Use Disorder criteria according to DSM-5
- Breath Alcohol Content (BrAC) of 0.00 at each visit
- In good health confirmed by medical history, physical exam, and lab tests
- Willing to follow study procedures
- Able to understand informed consent and questionnaires in English at an 8th grade level
You will not qualify if you...
- Women who are breastfeeding or have a positive urine pregnancy test
- Clinically significant medical problems such as unstable hypertension, abnormal ECG, high bilirubin, elevated liver enzymes, or low creatinine clearance
- Diagnosis of schizophrenia, bipolar disorder, or other psychoses
- Taking medications that reduce alcohol consumption (e.g., naltrexone, disulfiram)
- Using aspirin, penicillin, or methotrexate
- History of suicide attempts in the last three years
- Current moderate or severe cannabis use disorder
- Current diagnosis of other substance use disorders except nicotine
- Using medications that may interact with probenecid
- History of allergy to sulfa drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brown University
Providence, Rhode Island, United States, 02903
Actively Recruiting
Research Team
B
Brian Gully, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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