Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood.
Nathaniel D M Jenkins, Emily M Rogers, Nile F Banks...
https://pubmed.ncbi.nlm.nih.gov/34328346Actively Recruiting
Phase Not Applicable
Age: 18Years - 29Years
All Genders
Healthy Volunteers
ID07244809
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Led by University of Iowa · Updated on 2025-11-24
300
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
U
University of Iowa
Lead Sponsor
M
MitoQ Limited
Collaborating Sponsor
AI-Summary
What this Trial Is About
Adverse childhood experiences (ACEs), such as abuse and neglect during the first 18 years of life, are linked to a higher risk of cardiovascular diseases and death. This research investigates how mitochondrial dysfunction may contribute to impaired blood vessel function in young adults with a history of ACEs. The study aims to understand the biological causes of these vascular problems to help develop ways to reduce cardiovascular risks in affected individuals. Participants will receive either a single dose of a mitochondrial-targeted antioxidant supplement called Mitoquinone Mesylate (MitoQ) or a placebo. Before and after taking the supplement, blood vessel function will be measured using a special test called flow mediated dilation. Participants will then undergo a standardized psychosocial stress test while researchers collect blood samples and monitor vascular and stress responses to see if reducing mitochondrial oxidative stress improves these functions. During the study, participants will visit the lab to provide blood samples and undergo vascular function tests before and after supplementation. They will also be monitored during and after the stress test through blood pressure measurements, blood samples, and other cardiovascular assessments. The primary outcomes include changes in vascular function, blood pressure, endothelial cell microparticles, and cortisol levels, with additional measures of cardiac output and growth factors. The study will help identify how mitochondrial stress affects cardiovascular health in young adults with ACEs.
CONDITIONS
Brief Title
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Who Can Participate
Age: 18Years - 29Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 18 and 29 years
- Adverse Childhood Experience (ACE) score of 4 or higher
You will not qualify if you...
- Resting arterial blood pressure greater than 140/90 mmHg
- Body mass index (BMI) less than or equal to 17 or greater than or equal to 35
- Currently on a weight-loss diet, involved in a formal weight-loss program, or not weight stable within 6 months (plus or minus 5 kg)
- Use of cardiovascular or metabolic prescription drugs
- Use of vasoactive antidepressant drugs such as SSRIs or clonidine
- Current heavy alcohol use defined as binge drinking on 5 or more days in the last month or exceeding weekly drink limits
- Current or recent (within last 6 months) illicit drug use disorder with a high score on drug abuse screening
- Current tobacco or nicotine use
- Use of vaping products
- Regular vigorous aerobic exercise more than 4 times per week for over 30 minutes per session
- Use of dietary antioxidant supplements or habitual NSAID use
- Currently pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single day
Participants consume a single acute dose of either the mitochondrial targeted antioxidant supplement (MitoQ) or placebo. Vascular endothelial function and blood samples are collected before and after supplementation, followed by a standardized psychosocial stress test with additional blood sampling.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Integrative Laboratory of Applied Physiology and Lifestyle Medicine
Iowa City, Iowa, United States, 52242
Actively Recruiting
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Research Team
M
Manoela Lima Oliveria, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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Published Research Related To This Trial
The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms.
Shaoyong Su, Marcia P Jimenez, Cole T F Roberts...
https://pubmed.ncbi.nlm.nih.gov/26289252Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.
V J Felitti, R F Anda, D Nordenberg...
https://pubmed.ncbi.nlm.nih.gov/9635069