Actively Recruiting
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
Led by Leeds Beckett University · Updated on 2026-03-31
70
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
L
Leeds Beckett University
Lead Sponsor
C
Cultech Ltd, Port Talbot, UK
Collaborating Sponsor
AI-Summary
What this Trial Is About
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired glucose tolerance, a preclinical condition where blood glucose regulation is mildly disrupted. Seventy participants will be randomly assigned to receive either Lab4P or a placebo. The study will assess changes in memory, executive function, and processing speed, along with blood glucose control, cardiovascular function, cholesterol levels, body composition, and markers of inflammation. The study will also analyse changes in the gut microbiome and evaluate the safety and tolerability of the probiotic.
CONDITIONS
Official Title
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-40 years
- Body Mass Index (BMI) between 25.0 and 29.9 kg/m8 (classified as overweight)
- In good general health (self-reported)
- Normal self-reported sleep patterns, with no history of diagnosed sleep disorders
- Willing and able to provide informed consent
- Able to comply with study procedures, including fasting and oral glucose tolerance testing
You will not qualify if you...
- Diagnosed diabetes (any type)
- Diagnosed sleep disorders
- Fasting glucose >6.9 mmol/L during screening
- History of bariatric surgery (e.g., gastric bypass, sleeve gastrectomy)
- Major surgery, significant illness, trauma, infection, or myocardial infarction within the past 6 weeks
- Current use of medications affecting glucose metabolism or probiotics
- Pregnancy or actively trying to conceive
- Night shift work within the past month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Leeds Beckett University
Leeds, Greater Manchester, United Kingdom, LS1 3HE
Actively Recruiting
Research Team
L
Lewis F Hepburn
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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