Actively Recruiting
Probiotic in Patients With Bile Acid Malabsorption/Diarrhea
Led by Mayo Clinic · Updated on 2026-05-11
24
Participants Needed
1
Research Sites
77 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess effect of the DSF probiotic on fecal bile acid levels in patients with BAM.
CONDITIONS
Official Title
Probiotic in Patients With Bile Acid Malabsorption/Diarrhea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prior diagnosis of bile acid malabsorption based on either serum C4 >52.5 ng/mL, fecal 48h total bile acid excretion >2337 bcmol/48h, or primary bile acid >5% in 48h stool collection or >10% in a single stool sample
- Average stool consistency greater than 5 on the Bristol Stool Form Scale in a 7-day stool diary
- For women of childbearing potential: negative urine pregnancy test before starting treatment
- For women of childbearing potential: agreement to use approved contraception methods or total abstinence during the study unless post-menopausal
You will not qualify if you...
- Use of oral antibiotics or probiotics within 4 weeks before the study
- Pregnancy or lactation
- Use of bile acid sequestrants within 10 days before stool diary and during the study
- History of ileal resection
- Type 1 diabetes mellitus
- Body mass index of 40 kg/m or higher
- Gastrointestinal diseases associated with inflammation or recent gastrointestinal infection within 4 weeks
- Any condition or circumstance that could prevent compliance with study protocol or interfere with assessments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
J
John Damianos, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here