Study of Probiotic Streptococcus Salivarius M18 Lozenges to Reduce Dental Plaque in Orthodontic Patients

What this Trial Is About

Researchers are studying the effects of a probiotic lozenge containing the strain Streptococcus salivarius M18 on dental plaque formation, its makeup, and harmfulness in healthy patients receiving orthodontic treatment. This randomized, double-blind, placebo-controlled clinical trial aims to compare the probiotic treatment with a placebo control to better understand its impact on oral health in these patients. Participants will take a daily lozenge containing the probiotic strain or a placebo as part of the study. The trial is conducted in a triple-masked manner to ensure unbiased results. The primary measurement is the quantification of dental plaque after 6 weeks. Secondary measurements include the presence of S. salivarius, signs of gum inflammation, and plaque acidity immediately after the intervention. During the study, participants will be monitored for changes in dental plaque and oral health using various assessments. Researchers will evaluate plaque amount and composition, gingivitis levels, and plaque pH. The total study duration includes the 6-week treatment period and immediate post-intervention assessments. This trial is sponsored by the University of Aarhus and includes participants who have been receiving orthodontic treatment with fixed appliances for over 6 months.

Probiotic Treatment of Orthodontic Patients