Actively Recruiting
PROstate CAncer Real World Evidence Registry: Recurrent and Metastatic Prostate Cancer
Led by UroTrials Company (GmbH) · Updated on 2026-03-12
5000
Participants Needed
53
Research Sites
91 weeks
Total Duration
On this page
Sponsors
U
UroTrials Company (GmbH)
Lead Sponsor
N
Novartis Pharmaceuticals
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a prospective registry study to observe and document the treatment and disease progression in patients with recurrent and metastatic prostate cancer. The study includes four distinct patient groups based on disease status: those with biochemical recurrence after local treatment, non-metastatic castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and metastatic castration-resistant prostate cancer. Each group is enrolled and followed independently over different time periods to understand the course of therapy and disease. The study does not prescribe any specific treatment but records routine care as decided by each patient's physician. Data collection occurs during routine clinical visits at set intervals, including after enrollment, every 3 to 6 months, and when therapy changes occur. Standardized quality of life questionnaires (FACT-P and EQ-5D-5L) are completed, and biological samples are collected to support comprehensive assessment. Participants are followed long-term, with an average follow-up of seven years. Researchers document therapy patterns, disease management strategies, imaging assessments, patient-reported outcomes, treatment adherence, and adverse events throughout this period. The focus is on real-world data reflecting everyday clinical practice, enabling a detailed understanding of treatment effectiveness and disease progression in prostate cancer patients.
CONDITIONS
Brief Title
PROCARE - PROstate Cancer Real World Evidence Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult male patients aged 18 years or older
- Diagnosis of prostate cancer with one of the following: biochemical recurrence after local curative treatment, non-metastatic castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, or metastatic castration-resistant prostate cancer
- Patients starting a new line of systemic therapy at study entry or within 4 weeks
- Disease confirmed to be unsuitable for or declined local salvage treatment for cohorts 1, 2, and 3
- Ability and willingness to sign informed consent
You will not qualify if you...
- Patients deemed not eligible for observation due to severe comorbidities or unavailability as assessed by the treating physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 7 years
Participants who undergo routine care are observed over time. Routine data on disease course, therapy, quality of life questionnaires, and biomaterial are collected.
Visits every 3 to 6 months and when changing therapy
Trial Site Locations
Total: 53 locations
1
Universitätsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106
Actively Recruiting
2
National Center for Tumor Dieseases (NCT) Heidelberg
Heidelberg, Baden-Wurttemberg, Germany, 69120
Actively Recruiting
3
University Hospital Mannheim
Mannheim, Baden-Wurttemberg, Germany, 68167
Actively Recruiting
4
Medical Office for Urology Nürtingen
Nürtingen, Baden-Wurttemberg, Germany, 72622
Actively Recruiting
5
Studienpraxis Urologie
Nürtingen, Baden-Wurttemberg, Germany, 72622
Actively Recruiting
6
University Hospital Tübingen
Tübingen, Baden-Wurttemberg, Germany, 72076
Actively Recruiting
7
University Hospital Ulm
Ulm, Baden-Wurttemberg, Germany, 89081
Actively Recruiting
8
University Hospital Augsburg
Augsburg, Bavaria, Germany, 86156
Actively Recruiting
9
University Hospital Augsburg
Augsburg, Bavaria, Germany, 86156
Actively Recruiting
10
Hospital Bayreuth GmbH
Bayreuth, Bavaria, Germany, 95445
Actively Recruiting
11
University Hospital Erlangen
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
12
Hospital Kempten
Kempten (Allgäu), Bavaria, Germany, 87439
Actively Recruiting
13
Hospital Nürnberg North
Nuremberg, Bavaria, Germany, 90419
Actively Recruiting
14
Caritas-Hospital St. Josef
Regensburg, Bavaria, Germany, 93053
Actively Recruiting
15
University Hospital Würzburg
Würzburg, Bavaria, Germany, 97080
Actively Recruiting
16
"Vivantes Prostatazentrum" Hospital "am Urban"
Berlin, Brandenburg, Germany, 10967
Actively Recruiting
17
University Hospital Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
18
University Hospital Frankfurt/Main
Frankfurt am Main, Hesse, Germany, 60590
Actively Recruiting
19
Universitiy Hospital Gießen und Marburg GmbH, Site: Gießen
Giessen, Hesse, Germany, 35392
Actively Recruiting
20
Universital Hospital Gießen & Marburg GmbH, Site: Marburg
Marburg, Hesse, Germany, 35043
Actively Recruiting
21
Hospital Wetzlar
Wetzlar, Hesse, Germany, 35578
Actively Recruiting
22
Medical Office for Urology
Braunschweig, Lower Saxony, Germany, 38100
Actively Recruiting
23
Medical Office for Urology
Herzberg am Harz, Lower Saxony, Germany, 37412
Actively Recruiting
24
St. Bernward Hospital Hildesheim
Hildesheim, Lower Saxony, Germany, 31134
Actively Recruiting
25
St. Bernward Krankenhaus GmbH
Hildesheim, Lower Saxony, Germany, 31134
Actively Recruiting
26
Medical Office for Urology Altstadtquartier Magdeburg
Magdeburg, Lower Saxony, Germany, 39104
Actively Recruiting
27
MVZ Onco Medical GmbH Neustadt
Neustadt am Rübenberge, Lower Saxony, Germany, 31535
Actively Recruiting
28
Praxisgemeinschaft f. Onkologie & Urologie
Wilhelmshaven, Lower Saxony, Germany, 26389
Actively Recruiting
29
University Hospital Rostock
Rostock, Mecklenburg-Vorpommern, Germany, 18057
Actively Recruiting
30
University Hospital Aachen
Aachen, North Rhine-Westphalia, Germany, 52074
Actively Recruiting
31
Medical Office for Urology
Bayenthal, North Rhine-Westphalia, Germany, 50968
Actively Recruiting
32
Marien Hospital Bergisch Gladbach,
Bergisch Gladbach, North Rhine-Westphalia, Germany, 51465
Actively Recruiting
33
Johanniter GmbH, Johanniterkrankenhaus
Bonn, North Rhine-Westphalia, Germany, 53113
Actively Recruiting
34
Johanniter Hosptal Bonn
Bonn, North Rhine-Westphalia, Germany, 53113
Actively Recruiting
35
University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
36
Medical Office for Urology "Urologicum"
Duisburg, North Rhine-Westphalia, Germany, 47169
Actively Recruiting
37
University Hospital Düsseldorf
Düsseldorf, North Rhine-Westphalia, Germany, 40225
Actively Recruiting
38
University Hospital Essen
Essen, North Rhine-Westphalia, Germany, 45147
Actively Recruiting
39
Marien Hospital Herne, University Hospital der Ruhr-Universität Bochum
Herne, North Rhine-Westphalia, Germany, 44625
Actively Recruiting
40
"Brüder" Hospital St. Joseph Paderborn
Paderborn, North Rhine-Westphalia, Germany, 33098
Actively Recruiting
41
University Hospital Wuppertal
Wuppertal, North Rhine-Westphalia, Germany, 42283
Actively Recruiting
42
Medical Office for Urology
Würselen, North Rhine-Westphalia, Germany, 52146
Actively Recruiting
43
Urban Hospital Karlsruhe
Karlsruhe, Rhineland-Palatinate, Germany, 76133
Actively Recruiting
44
Hospital "Barmherzigen Brüder "Trier
Trier, Rhineland-Palatinate, Germany, 54292
Actively Recruiting
45
Center for Urology Boxberg
Neunkirchen, Saarland, Germany, 66538
Actively Recruiting
46
University Hospital Leipzig
Leipzig, Saxony, Germany, 04103
Actively Recruiting
47
City Hospital Dessau
Dessau, Saxony-Anhalt, Germany, 06847
Actively Recruiting
48
Universitiy Hospital Halle
Halle, Saxony-Anhalt, Germany, 06120
Actively Recruiting
49
University Hospital Halle
Halle, Saxony-Anhalt, Germany, 06120
Actively Recruiting
50
Urologie Altstadtquartier Magdeburg
Magdeburg, Saxony-Anhalt, Germany, 39104
Actively Recruiting
51
University Hospital Magdeburg
Magdeburg, Saxony-Anhalt, Germany, 39120
Actively Recruiting
52
Univerity Hospital Schleswig-Holstein
Lübeck, Schleswig-Holstein, Germany, 23562
Actively Recruiting
53
University Hospital Jena
Jena, Thuringia, Germany, 07747
Actively Recruiting
Research Team
A
Andrea Rößler, PhD
L
Lisa Marx-Blümel, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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