Comparison of Manual and Target Controlled Intravenous Anesthesia Using Processed EEG Monitoring in Adult Brain Tumor Surgery

What this Trial Is About

Researchers are evaluating anesthesia methods for adults undergoing planned surgery to remove brain tumors through craniotomy. The study compares two ways of delivering propofol and remifentanil anesthesia manual total intravenous anesthesia mTIVA and target controlled infusion TCI. The goal is to improve anesthesia monitoring using processed EEG pEEG to ensure proper anesthetic depth, which helps enable early neurological assessment and detection of complications after surgery. Participants receive general anesthesia with propofol and remifentanil, randomized to either mTIVA or TCI. The anesthesia depth is monitored with BIS, a processed EEG system, but the monitoring results are concealed from caregivers during surgery. The study measures the time spent within recommended pEEG levels from anesthesia start until surgery ends. Postoperative sedation is assessed using the Karolinska Sleepiness Scale KSS, and awareness is followed up 1 to 3 days after surgery. Participants are evaluated before surgery and consent to join. Data collected include demographics, tumor details, anesthesia records, and vital signs. Postoperative assessments include sedation levels and awareness checks. The study focuses on how anesthesia methods affect pEEG levels, drug use, time to regain consciousness, and sleepiness after surgery. The total participation involves preoperative assessment, surgery day monitoring, and postoperative follow-up for awareness and sedation.

Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery