Actively Recruiting
Prodromal Parkinsonian Features in GBA1 Mutation Carriers
Led by Shaare Zedek Medical Center · Updated on 2026-04-29
600
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating early signs of Parkinson's disease in people who carry mutations in the GBA1 gene, which is linked to Gaucher disease. The study aims to identify a subgroup at higher risk of developing Parkinson's, even up to twenty years before symptoms appear. This work compares carriers to diagnosed Gaucher patients and healthy individuals without the mutation to better understand pre-Parkinson's signs. Participants include carriers of Gaucher disease, Gaucher patients, and healthy controls. They will undergo a range of non-invasive tests such as sensory evaluations, blood tests, blood pressure measurements in different positions, brain ultrasound, neurological examinations, and questionnaires. These assessments are designed to evaluate different aspects related to Parkinson's disease. During the study, participants will be regularly monitored through these tests to build a model identifying those carriers prone to Parkinson's disease by assessing anatomical, cognitive, mental, sleep, and motor domains. The study lasts up to eight years, allowing long-term observation. The research is observational and does not involve treatment but offers potential for future preventive measures if available.
CONDITIONS
Brief Title
Prodromal Parkinsonian Features in GBA1 Mutation Carriers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to participate
You will not qualify if you...
- Parkinson's disease patients
- Dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 years
Participants undergo a series of non-invasive tests including sensory tests, blood tests, blood pressure measurements, brain ultrasound, neurological tests, and questionnaires to assess pre-Parkinsonian signs.
Periodic visits over 8 years
Trial Site Locations
Total: 1 location
1
Michal Becker- Cohen
Jerusalem, Please Select..., Israel, 9103102
Actively Recruiting
Research Team
A
Ari Zimran, MD
M
Michal Becker- Cohen, M.Sc.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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