Actively Recruiting
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
Led by University Hospital, Grenoble · Updated on 2024-02-20
707
Participants Needed
1
Research Sites
363 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Grenoble
Lead Sponsor
E
Etablissement Français du Sang
Collaborating Sponsor
AI-Summary
What this Trial Is About
Despite being standard of care, there are still many medical requirements related to immune checkpoint blocker based therapies such as identify patients susceptible to respond with the less adverse events, evaluate the clinical benefit of adjuvant treatment /risk of relapse and design new strategies for non-responder patients. Thus, this project aims at understanding the impact of anti-PD1 on the immune system through investigation of the phenotypic, functional, metabolic and transcriptomic profiles of circulating DC subsets and effectors in response to anti-PD1 therapy in melanoma patients. The primary objective of the study is to identify the biomarkers of response to anti-PD1 according to the type of patient before the start of the treatment.
CONDITIONS
Official Title
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient with histologically confirmed melanoma (stage I, II, III or IV based on AJCC classification)
- Able to sign the informed collection consent for the retrospective part or to express their non-opposition to the research for the prospective part of the study
You will not qualify if you...
- Subject under guardianship or subject deprived of freedom
- Persons benefiting from special protection such as minors, pregnant or breastfeeding women, adults protected by law (under guardianship, curatorship or deprived of liberty), and persons hospitalized without their consent
- Ocular melanoma
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU Grenoble Alpes
Grenoble, France, 38043
Actively Recruiting
Research Team
J
Julie Charles, MD, PhD
CONTACT
S
Stéphane Mouret, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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