Actively Recruiting
Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Cancer
Led by European Institute of Oncology · Updated on 2024-11-27
60
Participants Needed
1
Research Sites
317 weeks
Total Duration
On this page
Sponsors
E
European Institute of Oncology
Lead Sponsor
A
AIRC (Italian Association for Cancer Research)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Investigators have recently shown that epigenetic remodelling enzymes, such as HDAC inhibitors, are feasible drugs in HNC (8, 9). Preliminary data are indicating some deregulated epigenetics marks suggesting the corresponding histone modifiers as possible targets for the treatment of HNC, providing an attractive and feasible option to build upon. Our overarching hypothesis is that unique histone marks distinguish HPV+ and HPV- HNC and that specific histone modifiers are novel mediators of HNC tumorigenesis in an HPV specific manner
CONDITIONS
Official Title
Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 60; 18 years diagnosed with head and neck cancer
- Both male and female participants
- Human papillomavirus (HPV) test results positive or negative
- Primary tumors, treatment-naive, squamous cell carcinoma
- Cancer stages I through IV
- Tumors located in the oral cavity, larynx, or oropharynx
- Tumor fragments are not required for diagnostics
You will not qualify if you...
- Previous radiotherapy, chemotherapy, or immunotherapy for head and neck cancer
- Unable to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
European Institute of oncology
Milan, MI, Italy, 20141
Actively Recruiting
Research Team
S
Susanna Chiocca, Doctor
CONTACT
F
francesca lombardi, dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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