Study of Spasticity Development and Diagnosis in Adults After Acute Stroke in the Middle Cerebral Artery Area

What this Trial Is About

This research aims to study the natural development of spasticity, which is increased muscle resistance, in patients who have had a stroke. The focus is on how spasticity evolves in the first three months after stroke, especially in elbow and ankle muscles. The study will compare a new neurophysiological measure called the tonic stretch reflex threshold angle TSRT and its velocity sensitivity mu with common clinical tests like the Modified Ashworth Scale MAS. Brain imaging will also be used to explore how brain damage relates to spasticity development. Participants will undergo 12 weekly evaluations starting within the first week after their stroke. At around week 6, they will have detailed brain MRI scans. A follow-up assessment will be done at week 16. These assessments include measuring TSRT, mu, MAS, and reflexes, along with other motor function tests such as active and passive range of motion, strength, balance, and mobility tests. During the study, participants will be assessed at the bedside weekly for 12 weeks, with a final follow-up at week 16 to track changes in spasticity and motor abilities. The researchers will gather data on brain imaging and clinical measures to understand the relationship between brain injury and spasticity. This information will help evaluate how early and accurately spasticity can be detected and how it impacts recovery in stroke patients.

Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients