Actively Recruiting
Changing Practice: Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients: a Pilot Study
Led by McGill University · Updated on 2025-06-04
12
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study the natural development of spasticity, which is increased muscle resistance, in patients who have had a stroke. The focus is on how spasticity evolves in the first three months after stroke, especially in elbow and ankle muscles. The study will compare a new neurophysiological measure called the tonic stretch reflex threshold angle (TSRT) and its velocity sensitivity (mu) with common clinical tests like the Modified Ashworth Scale (MAS). Brain imaging will also be used to explore how brain damage relates to spasticity development. Participants will undergo 12 weekly evaluations starting within the first week after their stroke. At around week 6, they will have detailed brain MRI scans. A follow-up assessment will be done at week 16. These assessments include measuring TSRT, mu, MAS, and reflexes, along with other motor function tests such as active and passive range of motion, strength, balance, and mobility tests. During the study, participants will be assessed at the bedside weekly for 12 weeks, with a final follow-up at week 16 to track changes in spasticity and motor abilities. The researchers will gather data on brain imaging and clinical measures to understand the relationship between brain injury and spasticity. This information will help evaluate how early and accurately spasticity can be detected and how it impacts recovery in stroke patients.
CONDITIONS
Brief Title
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute stroke in Middle Cerebral Artery area resulting in hemiparesis
- Hemorrhagic or ischemic stroke
- Medically stable
- Able to provide informed consent
- Age between 18 and 85 years
You will not qualify if you...
- Severe cognitive disorders
- Ataxia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants undergo weekly evaluations to assess various measures related to spasticity and motor function starting within the first week post-stroke.
Weekly visits for up to 12 weeks
Duration - 1 day
Participants receive an MRI scan as part of the assessment of spasticity and stroke recovery.
1 visit (in-person)
Duration - 1 week
Participants complete a follow-up assessment to monitor ongoing recovery and spasticity status after the initial evaluation period.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
Research Team
M
Mindy F. Levin, PT, PhD
A
Alice Misana, PT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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