Actively Recruiting
Prognosis Stratification for Advanced HCC Receiving TACE with PD-1/PD-L1 Inhibitors and Molecular Target Therapies
Led by Zhongda Hospital · Updated on 2024-09-23
950
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to establish a personalized model of prognosis stratification for patients with advanced-stage hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) and molecular target therapies.
CONDITIONS
Official Title
Prognosis Stratification for Advanced HCC Receiving TACE with PD-1/PD-L1 Inhibitors and Molecular Target Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of hepatocellular carcinoma confirmed by radiology, histology, or cytology
- Barcelona Clinic Liver Cancer (BCLC) stage C with extrahepatic spread and/or macrovascular invasion
- No prior systemic therapy for HCC, including chemotherapy, targeted therapy, or immunotherapy
- Use of marketed PD-1/PD-L1 inhibitors and anti-angiogenesis drugs, not limited to HCC approval
- TACE performed within 3 months before or after first PD-1/PD-L1 inhibitor or anti-angiogenic drug treatment
- Received at least one cycle of PD-1/PD-L1 inhibitor plus anti-angiogenic drug combination therapy after TACE
- Presence of repeated measurable intrahepatic lesions
You will not qualify if you...
- Diagnosis of cholangiocarcinoma, fibrolamellar, sarcomatoid HCC, or mixed hepatocellular/cholangiocarcinoma subtypes confirmed by histology or pathology
- Inability to meet the specified combination therapy timing
- Child-Pugh class C liver function, performance status greater than 2, or severe hepatic encephalopathy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhongda Hospital
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
G
Gao-Jun Teng, M.D
CONTACT
H
Hai-Dong Zhu, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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