Actively Recruiting
Prognostic Biomarkers for Pulpotomy Outcome
Led by The University of Hong Kong · Updated on 2024-07-23
192
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will recruit 180 molars diagnosed with irreversible pulpitis. Full pulpotomy will be performed on 120 teeth, while RCT (root canal treatment) will be conducted on another cohort of 60 teeth as the control for assessing long-term outcomes. Additionally, 12 blood samples and pulp tissues from healthy teeth receiving elective RCT will be collected as the controls. The first pulpal blood sample will be collected after caries removal and pulp exposure. Subsequently, the entire coronal pulp tissue will be removed and collected for histological examination, image-based spatial and scRNA-seq analyses. A second pulpal blood sample will be collected from the radicular pulp tissue. Both blood samples will be used to profile the inflammation-related biomarkers through multiplex immunoassays. The remaining pulp tissue will be covered by Biodentine and restored with resin-based composite. Pulpotomy treatment outcomes will be evaluated clinically and radiographically at 6 and 12 months. The biomarkers identified in the pulpal blood and histology and the single-cell transcriptomes of the coronal pulp will be compared with the treatment "success" and "failure" groups upon one year. The outcome of RCT will be compared with that of full pulpotomy at 24 months.
CONDITIONS
Official Title
Prognostic Biomarkers for Pulpotomy Outcome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Permanent molars with deep carious lesions extending close to the pulp chamber
- Clinical diagnosis of irreversible pulpitis with spontaneous or lingering pain and specific cold test responses
- Positive response to cold and electric pulp tests
You will not qualify if you...
- Teeth with no response to cold or electric tests, apical radiolucency beyond periodontal widening, canal calcification or resorption
- History of dental trauma, unrestorable or nonfunctional teeth, or perio-endo lesions
- Intraoperative bleeding longer than 10 minutes or insufficient pulpal blood sample
- Patients with compromised immune status or recent use of analgesics or antibiotics within one week
AI-Screening
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Trial Site Locations
Total: 1 location
1
Clinical Research Centre, Faculty of Dentistry, The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
R
Rong Cen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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