Study of Factors Affecting Recovery of Consciousness in Early Neurological Rehabilitation In Adults With Severe Brain Injury or Stroke

What this Trial Is About

This research aims to identify factors that predict medium and long-term recovery outcomes for patients with disorders of consciousness undergoing early neurological rehabilitation. It focuses on patients with severe brain injuries such as stroke, traumatic brain injury, or hypoxic-ischemic encephalopathy, who remain in altered states of consciousness like coma, unresponsive wakefulness syndrome, or minimally conscious state. The study is prospective and observational, enrolling 130 patients over 36 months to better understand the prognosis and treatment options based on detailed patient assessments. Patients admitted to intensive care units after severe brain injury will be observed without any intervention, as this is an observational study. Routine clinical data, disease severity, and functional status will be recorded at study entry. Within the first week, MRI scans, EEGs, and evoked potentials will be measured and then repeated after eight weeks. The level of consciousness will be regularly assessed weekly using the Coma-Recovery-Scale-Revised. Follow-up evaluations with the Glasgow Outcome Scale-Revised will occur at 3, 6, and 12 months to track progress. Participants will undergo weekly assessments of consciousness level, functional status, and monitoring for complications or other health conditions. Researchers will use these measurements to evaluate changes in functional status and consciousness over time, with a focus on outcomes at eight weeks. The study includes detailed imaging and electrophysiological tests to support these evaluations. Total participation may last up to a year with follow-ups to monitor recovery and outcomes, ensuring comprehensive data collection on neurological rehabilitation progress.

Prognostic Factors to Regain Consciousness