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A Multi-center Prospective Study to Develop and Validate a Prognostic Model for Drug-induced Liver Injury in China
Led by Beijing Friendship Hospital · Updated on 2025-09-22
3000
Participants Needed
13
Research Sites
104 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are conducting a prospective, multi-center observational study in China to better understand drug-induced liver injury DILI. The study aims to explore the clinical features, identify the drugs or herbs causing DILI, assess patient outcomes, and discover new serum markers. The goal is to develop and validate a prognostic model incorporating these novel markers to improve prediction of patient prognosis in China. Participants will be grouped into a modeling group to help build a predictive model for DILI outcomes, and a validation group to test the accuracy of this model. The study collects long-term data to establish and verify these prognostic tools. No experimental treatments are given as this is an observational cohort study. During the study, researchers will monitor participants for key outcomes such as death, liver transplantation, and acute liver failure over one year, as well as chronic DILI and recovery over two years. Data will be collected through regular clinical assessments and laboratory tests. This long-term follow-up will help improve understanding of DILI prognosis and validate new serum biomarkers. Participants will be involved over extended periods to ensure comprehensive outcome measurement.
CONDITIONS
Brief Title
A Prognostic Model for Drug-induced Liver Injury in China
Research Team
Y
Yan Wang
Z
Zikun Ma
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