Actively Recruiting
A Prognostic Model for Drug-induced Liver Injury in China
Led by Beijing Friendship Hospital · Updated on 2025-09-22
3000
Participants Needed
13
Research Sites
344 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and screen novel serum markers. A prognostic model incorporating with the novel serum marker(s) for DILI would be established and validated to imporve the prognosis of patients in China .
CONDITIONS
Official Title
A Prognostic Model for Drug-induced Liver Injury in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- RUCAM score 6 or higher with at least one of these: ALT at least 5 times the upper limit of normal (ULN), ALP at least 2 times ULN, or ALT at least 3 times ULN and total bilirubin (TBil) at least 2 times ULN
- RUCAM score between 3 and 5 with diagnosis agreed by at least 4 out of 5 experienced hepatologists
- Onset of liver injury symptoms within 3 months before enrollment
You will not qualify if you...
- Infection with hepatitis A, B, C, D, or E viruses
- Infection with non-hepatotropic viruses like cytomegalovirus or Epstein-Barr virus
- Hypoxic ischemic hepatitis or congestive liver disease
- Alcohol consumption over 40g/day for males or 20g/day for females for 5 or more years
- Biliary obstruction, primary biliary cholangitis, or primary sclerosing cholangitis
- Autoimmune hepatitis with specific diagnostic scores or unclear differentiation
- Parasitic infection
- Sepsis
- Previous liver or bone marrow transplantation
- Pregnancy or breastfeeding
- Genetic or metabolic liver diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Beijing 302 Hospital
Beijing, Beijing Municipality, China, 100166
Actively Recruiting
2
Beijing Friendship Hospital, Capital Medical University
Beijing, China, 100050
Actively Recruiting
3
Beijing You 'an Hospital, Capital Medical University
Beijing, China, 100069
Actively Recruiting
4
Beijing Ditan Hospital
Beijing, China, 100102
Active, Not Recruiting
5
Peking University Third Hospital
Beijing, China, 100191
Active, Not Recruiting
6
The Second Affiliated Hospital of Dalian Medical University
Dalian, China, 116023
Actively Recruiting
7
Qinzhou First People's Hospital
Guangxi, China, 535009
Active, Not Recruiting
8
Hebei CNPC Central Hospital
Hebei, China, 050011
Active, Not Recruiting
9
Jiaozuo People's Hospital
Jiaozuo, China, 454002
Actively Recruiting
10
The Second Hospital of Lanzhou University
Lanzhou, China, 730046
Actively Recruiting
11
The Affiliated Hospital of Qingdao University
Qingdao, China, 266003
Actively Recruiting
12
Qinghai People's Hospital
Qinghai, China, 810007
Actively Recruiting
13
Yuncheng Central Hospital
Yuncheng, China, 044099
Actively Recruiting
Research Team
Y
Yan Wang
CONTACT
Z
Zikun Ma
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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