Actively Recruiting
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Led by Sied Kebir · Updated on 2025-07-08
128
Participants Needed
2
Research Sites
295 weeks
Total Duration
On this page
Sponsors
S
Sied Kebir
Lead Sponsor
M
Münster University Hospital, Germany
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data. In addition, neurocognitive tests will be carried out to correlate the results of olfactory function with the patient's cognitive abilities. Investigations into the quality of life and psychological condition of the patients are also performed. In addition to the cohort of glioblastoma patients, there is a control cohort without tumor disease in which the olfactory testing is also carried out in order to have a comparison.
CONDITIONS
Official Title
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years of age
- Newly-diagnosed glioblastoma (IDH wild-type)
- Never received prior chemotherapy
- Never received radiotherapy to the head or neck before
- Karnofsky performance status (KPS) of 70 or higher
- No history of severe head or brain trauma requiring ICU admission or Glasgow Coma Scale grade 3
- No respiratory infection at the time of inclusion
- No significant aphasia
You will not qualify if you...
- Presence of neurodegenerative diseases (e.g., Parkinson's, Alzheimer's, Huntington's, Korsakoff's, Pick's, Shy-Drager syndrome)
- History of invasive tumors or surgery in the head or neck area, except for non-invasive skin tumor surgeries
- Permanent loss of smell following infections (e.g., influenza, coronavirus)
- Conditions that may interfere with study participation (e.g., schizophrenia)
- Language barriers likely to affect participation or understanding of study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University Hospital Essen, Department of Neurology, Division of Clinical Neuro-Oncology
Essen, Germany, 45147
Actively Recruiting
2
Department of Neurosurgery
Münster, Germany
Actively Recruiting
Research Team
C
Christoph Oster, Dr. med.
CONTACT
S
Sied Kebir, PD Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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