Actively Recruiting
Prognostic and Predictive Biomarkers in Ovarian Cancers
Led by Gustave Roussy, Cancer Campus, Grand Paris · Updated on 2026-03-20
350
Participants Needed
1
Research Sites
831 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators therefore propose to conduct a biological study of prospectively collected patient tumour samples, ascites, blood and other residual samples (feces, urine, vaginal smear) throughout the disease course where markers (at diagnosis and their change with treatment) will be correlated to outcome in order to investigate how genetic diversity in OC prior to treatment and adaptation following treatment contribute to chemotherapy resistance. In addition freshly collected ascitic samples (and tumour samples) will be subjected to ex vivo DNA repair functional assays and isolated in primary culture (and established as xenografts) for target validation experiments.
CONDITIONS
Official Title
Prognostic and Predictive Biomarkers in Ovarian Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New patient with a diagnosis of ovarian cancer, or
- Previously treated patient with frozen or formalin fixed paraffin embedded primary tumor sample available that can be retrieved by the center presenting with progressive disease and consenting to biopsy of relapsed disease, or
- Previously treated patient with frozen or formalin fixed paraffin embedded primary tumor sample available scheduled for surgery for relapsed disease
- Signed informed consent
- Age 18 years or older
- Patient affiliated to a social security regimen or beneficiary of the same
You will not qualify if you...
- Patients who do not meet inclusion criteria or refuse antitumoral treatment
- Coagulation abnormalities that prevent biopsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Gustave Roussy
Villejuif, Val de Marne, France, 94805
Actively Recruiting
Research Team
A
Alexandra LEARY, MD
CONTACT
D
Damien DRUBAY
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here