Actively Recruiting
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Led by University of Texas Southwestern Medical Center · Updated on 2026-02-27
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the use of Hyperpolarized 13C MRI, a noninvasive imaging technique, to evaluate heart metabolism in people with heart failure due to coronary artery disease. This study aims to improve how patients are selected for coronary artery bypass surgery by measuring the bicarbonate-to-lactate ratio in the heart muscle. The research compares these measurements before and after surgery with values from healthy volunteers to better understand heart metabolism in these groups. Participants include healthy volunteers aged 20 to 80 years with no history of coronary artery disease or diabetes, and patients scheduled for coronary artery bypass surgery who have one or more blocked coronary vessels. The study involves MRI scans at baseline for healthy subjects, preoperative imaging for surgery patients, and follow-up imaging 4 to 6 months after surgery. The research also examines the safety and reproducibility of the Hyperpolarized 13C pyruvate used during the MRI. During the study, participants will undergo MRI exams to measure the bicarbonate-to-lactate ratio, alongside blood tests to assess related metabolic markers like pyruvate and insulin. Echocardiograms will assess heart wall motion to explore links between metabolism and heart function. The study tracks changes over time, focusing on heart metabolism before and after surgery, with safety and tolerability monitored throughout. The total participation period can extend from initial imaging to months following surgery.
CONDITIONS
Brief Title
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 80 years
- Male or female participants
- Preoperative patients with left ventricular ejection fraction (LVEF) less than 0.35
- Healthy subjects with LVEF greater than 0.50
- Patients scheduled for coronary artery bypass surgery with one or more stenotic coronary vessels
- Blood pressure below 140/90 mm Hg
- Heart rate around 78 beats per minute
- Hypertension allowed
- Current smokers allowed but will be reported
- Medication use within 24 hours will be recorded
You will not qualify if you...
- History of myocardial infarction excluded for healthy subjects
- Diabetes mellitus excluded for all participants
- Coronary artery bypass surgery history excluded for healthy subjects
- Infarct type and location excluded for healthy subjects
- Number of diseased coronary vessels excluded for healthy subjects
- Other medical histories or clinical data varying by physician practices may exclude participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo noninvasive hyperpolarized 13C MRI to assess myocardial metabolism and related blood measurements.
1 visit (in-person)
Duration - 4 to 6 months
Participants who have undergone coronary artery bypass surgery are followed up 4 to 6 months postoperatively for repeated MRI evaluation and assessment of myocardial metabolism changes.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
S
Sarah S McNeil
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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