Actively Recruiting
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Led by University of Texas Southwestern Medical Center · Updated on 2026-02-27
30
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern. Nevertheless, the optimal approach for patient selection based on conventional imaging scans remains unclear. The proposed method (Hyperpolarized 13C MRI) has gained extensive use in evaluating in vivo metabolism. This method avoids ionizing radiation and provides critical insights into cardiac function. The feasibility study aims to investigate this method for patient selection before bypass surgery. This innovative imaging technique facilitates the identification of two simple molecules, bicarbonate and lactic acid, produced at high rates by normal heart metabolism. Both bicarbonate and lactate originate from the same precursor molecule, pyruvate. The data generated from this study holds the potential to refine diagnostic precision.
CONDITIONS
Official Title
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 80 years
- Random allocation of sex
- Preoperative patients with left ventricular ejection fraction (LVEF) less than 0.35
- Healthy subjects with LVEF greater than 0.50
- Hypertension allowed with systolic blood pressure less than 140 mm Hg and diastolic less than 90 mm Hg
- Mean heart rate approximately 78 beats per minute
- Current smokers allowed but smoking status will be recorded
- Medication use within 24 hours will be recorded
- Preoperative patients with a history of previous myocardial infarction
- Preoperative patients with at least one diseased coronary vessel
- Preoperative patients with various types and locations of Q-wave infarcts
- Variations in additional medical history and clinical data will be documented
You will not qualify if you...
- Healthy subjects with a history of previous myocardial infarction
- Participants with diabetes mellitus
- Healthy subjects with a history of coronary artery bypass surgery
- Participants outside the age range of 20 to 80 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
S
Sarah S McNeil
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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