Actively Recruiting
Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications
Led by University of Rijeka · Updated on 2026-05-07
200
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity. The study will assess their association with obesity status, metabolic complications, lifestyle patterns, dietary indices, and established inflammatory biomarkers. Participants will undergo anthropometric assessment, laboratory testing, dietary evaluation, and follow-up for response to different obesity treatment modalities over 3 years. The study intends to determine whether SII and SIRI can serve as clinically useful predictors of metabolic risk and treatment outcomes of obesity.
CONDITIONS
Official Title
Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Body mass index (BMI) between 25.0 and 29.9 kg/m8 (overweight) or BMI 30 kg/m8 or higher (obesity)
- Ability to attend scheduled clinical visits
- Willingness to provide informed consent
You will not qualify if you...
- Pregnancy or breastfeeding
- Use of immunosuppressive therapy
- Active infection
- Inflammatory disease
- Malignancy
- Acute illness affecting immune parameters
- Conditions interfering with study participation as assessed by the investigator
- Known hematologic disorders affecting leukocyte or platelet counts
- Chronic inflammatory diseases requiring systemic therapy
- Recent major surgery within the last 3 months
- Any condition that could confound the relationship between SII/SIRI and obesity-driven inflammation, such as immune disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
General Hospital Varaždin
Varaždin, Croatia
Actively Recruiting
Research Team
G
Gordana Kenđel Jovanović, Asst.Prof.
CONTACT
J
Jelena Vresk Špiranec, MD, spec. endocrinology
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here