Actively Recruiting
Evaluation of Coronary Artery Plaque Progression by CT Angiography and Intracoronary Imaging in Patients With Coronary Artery Disease
Led by Ruijin Hospital · Updated on 2025-01-27
50000
Participants Needed
2
Research Sites
752 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted after 2 years. Comprehensive morphological and functional plaque analysis will be performed. The impact of these morphological and functional parameters, alongside cardiometabolic factors and pharmacological treatments on plaque progression and the occurrence of major adverse cardiovascular events (MACEs) will be analyzed. In addition, intracoronary imaging techniques will be used to improve the accuracy of plaque analysis by coronary CTA.
CONDITIONS
Official Title
PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age ≥ 18 years
- Clinically significant angina pectoris, or suspected CAD
- Receive coronary CTA scan, with a visible plaque (defined as ≥25% diameter stenosis) in major coronary arteries.
You will not qualify if you...
- Unsuitable for coronary CTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)
- Receive percutaneous coronary intervention (PCI) within 6 months
- Prior history of myocardial infarction or heart failure
- Prior history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
- Abnormal liver function (serum alanine aminotransferase [ALT] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30 ml/min)
- Familial hypercholesterolemia
- Estimated survival ≤ 1 year
- Malignant tumor
- Pregnant or lactation, or have the intention to give birth within one year
- Poor coordinance, unable to follow-up
AI-Screening
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Trial Site Locations
Total: 2 locations
1
CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital
Shanghai, China, 200000
Actively Recruiting
2
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China, 200025
Actively Recruiting
Research Team
X
Xiaoqun Wang
S
Shuo Feng
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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