Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K G Alberti, P Z Zimmet
https://pubmed.ncbi.nlm.nih.gov/9686693Actively Recruiting
Age: 18Years - 45Years
FEMALE
Healthy Volunteers
ID05935904
The Progression of Metabolic Syndrome Components During Pregnancy and Risks for Adverse Pregnancy Outcomes in Southwest Ethiopia: A Prospective Cohort Study
Led by University Ghent · Updated on 2024-07-08
526
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University Ghent
Lead Sponsor
F
Flemish Interuniversity Council (VLIR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand how metabolic syndrome (MetS) develops during pregnancy and how it affects birth outcomes in low-risk pregnant women attending their first antenatal care visit in southwest Ethiopia. The study seeks to identify risk factors influencing MetS progression and examine how MetS components early and late in pregnancy relate to complications such as preeclampsia and gestational diabetes. It also explores women's knowledge, attitudes, and dietary practices during pregnancy. Pregnant women will be observed across four visits: at enrollment before 15 weeks, mid-pregnancy at 24 weeks, late pregnancy at 36 weeks, and within two weeks after delivery. Data collected will include dietary intake, biochemical tests, body measurements, and information about pregnancy and birth outcomes. A subgroup will have body composition measured to help define obesity cutoffs relevant to this population. Participants will provide information on lifestyle and health at each visit, and newborns will be assessed for weight, length, head size, and Apgar score shortly after birth. Researchers will analyze changes in MetS markers, dietary habits, and pregnancy outcomes, monitoring maternal health and newborn status up to one month postpartum. The study aims to develop context-specific tools to identify and manage MetS risk during pregnancy.
CONDITIONS
Brief Title
Progression of Metabolic Syndrome Components During Pregnancy
Who Can Participate
Age: 18Years - 45Years
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
- Pregnant and less than 15 weeks into pregnancy
- Generally healthy with or without at least one metabolic syndrome component
- For the exposed group, presence of one or more risk factors such as abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, or raised plasma glucose
- Attending first antenatal care visit at selected health institutions
- Willing to participate and adhere to follow-up visits
You will not qualify if you...
- Chronic hypertension requiring medication
- Diabetes under medication
- Severe chronic illnesses
- HIV positive and on antiretroviral therapy
- Women under 18 years old
- Planning to move out of the study area during the study period
- Unwilling to follow-up for the study duration
- Twin pregnancy confirmed by ultrasound
- Fetal congenital anomaly or fetal death in utero
AI-Screening
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1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 28 weeks
Participants are observed throughout pregnancy to assess the progression of metabolic syndrome components and collect data on dietary habits, nutritional status, and biochemical indicators.
4 visits: at enrollment (≤15 weeks), mid-pregnancy (24 weeks), late pregnancy (36 weeks), and within two weeks postpartum
Trial Site Locations
Total: 1 location
1
Jimma University Medical Center
Jimma, Ethiopia
Actively Recruiting
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Research Team
S
Souheila Abbeddou, MSc. PhD
A
Abonesh Taye Kumsa, MSc.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Gestational diabetes mellitus increased the risk of adverse neonatal outcomes: A prospective cohort study in Northwest Ethiopia.
Achenef Asmamaw Muche, Oladapo O Olayemi, Yigzaw Kebede Gete
https://pubmed.ncbi.nlm.nih.gov/32447182Food taboos and nutrition-related pregnancy concerns among Ethiopian women.
Vidanka Vasilevski, Mary Carolan-Olah
https://pubmed.ncbi.nlm.nih.gov/27411855Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study.
Abadi Kidanemariam Berhe, Abiodun O Ilesanmi, Christopher O Aimakhu...
https://pubmed.ncbi.nlm.nih.gov/31892353The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus.
L Chatzi, E Plana, A Pappas...
https://pubmed.ncbi.nlm.nih.gov/19897394Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women.
Jessica A Grieger, Tina Bianco-Miotto, Luke E Grzeskowiak...
https://pubmed.ncbi.nlm.nih.gov/30513077Prevalence of Metabolic Syndrome in Women After Maternal Complications of Pregnancy: An Observational Cohort Analysis.
Emily Aldridge, Maleesa Pathirana, Melanie Wittwer...
https://pubmed.ncbi.nlm.nih.gov/35360031