Actively Recruiting
Project COMET: Massed Prolonged Exposure for PTSD and SUD
Led by Rutgers, The State University of New Jersey · Updated on 2025-10-27
168
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
R
Rutgers, The State University of New Jersey
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program
CONDITIONS
Official Title
Project COMET: Massed Prolonged Exposure for PTSD and SUD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18+
- Enrolled in SUD treatment at Gateway Community Services
- Meet DSM-5 criteria for a SUD (Tobacco Use Disorder alone not sufficient for inclusion)
- Meet DSM-5 criteria for PTSD
- Able to give informed consent
You will not qualify if you...
- severe cognitive impairment
- current suicidal or homicidal intent requiring immediate treatment
- current unstable psychotic or manic symptoms not attributable to SUD
AI-Screening
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Trial Site Locations
Total: 1 location
1
Gateway Community Services
Jacksonville, Florida, United States, 32204
Actively Recruiting
Research Team
D
Denise Hien Helen E. Chaney Endowed Chair in Alcohol Studies, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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