Actively Recruiting
Project SIRT6 Activator
Led by National University of Singapore · Updated on 2026-03-30
60
Participants Needed
2
Research Sites
130 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
U
University of Rochester
Collaborating Sponsor
AI-Summary
What this Trial Is About
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process could prevent or delay multiple diseases, enhancing healthspan. Fucoidan, a sulfated polysaccharide from brown macroalgae, is a safe dietary supplement with Sirtuin-6 (SIRT6) activating properties, which are linked to longevity. Clinical studies have shown that it reduces inflammatory markers associated with biological aging and frailty and influences DNA methylation in vitro and in vivo; however, its effects on human DNA methylation remain unknown.
CONDITIONS
Official Title
Project SIRT6 Activator
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male aged 50 to 80 years
- Resident of Singapore (citizenship or permanent residency not required)
- Prefrail according to Fried frailty phenotype score
- Able to understand, read, and write in English
- No severe cognitive impairment as judged by the investigator
- Apparently healthy nonsmokers with no more than two stable conditions among hypertension, hyperlipidemia, hyperglycemia, osteopenia/osteoporosis, osteoarthritis, COPD, or type 2 diabetes
- Agree to shave dense facial hair one day before visits if it may interfere with skin microbiome sampling
You will not qualify if you...
- History or presence of major cardiovascular diseases such as coronary artery disease, heart failure, stroke, or peripheral vascular disease
- Current cancer or unstable chronic obstructive pulmonary disease (COPD)
- Use of anticoagulant medication
- Consuming seaweed more than three times a week
- Presence of hairiness, moles, tattoos, scars, or irritated skin on the face that may affect the study
- Use of systemic or topical antibiotics for more than three consecutive days within the past three weeks or planned use during the study
- Positive serology for HIV, hepatitis B, or hepatitis C (for those undergoing skin microbiopsy sampling)
- Contraindications for skin microbiopsies including hypersensitivity to local anesthesia or antibiotics, bleeding disorders, use of anticoagulants, or history of wound healing problems such as hypertrophic scars or keloids
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Yong Loo Lin School of Medicine, National University of Singapore
Singapore, Singapore, Singapore, 117597
Actively Recruiting
2
NUS Academy for Healthy Longevity, Level 6, MD 11, 10 Medical Dr, Yong Loo Lin School of Medicine, National University of Singapore
Singapore, Singapore
Not Yet Recruiting
Research Team
A
Andrea Britta Maier, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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