Actively Recruiting
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Led by Institute for Clinical and Experimental Medicine · Updated on 2026-04-14
12
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
CONDITIONS
Official Title
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Left ventricular ejection fraction less than 35%
- Acute heart failure with low cardiac output syndrome or cardiogenic shock
- Adults aged 18 years or older
You will not qualify if you...
- Severe liver failure
- Severe acidosis
- Inability to insert nasogastric tube
- Gastric paralysis or ileus
- Repeated vomiting
- Severe hypokalemia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Institute for Clinical and Experimental Medicine (IKEM)
Prague, Prague, Czechia, 14021
Actively Recruiting
Research Team
M
Marek Sramko, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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