Actively Recruiting
PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms
Led by Jeffrey Pernica · Updated on 2026-04-29
698
Participants Needed
6
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In North America, up to 5% of preschoolers develop community-acquired pneumonia (CAP) every year. Pneumonia is the second-leading reason for paediatric hospitalization in both Canada and the US; approximately 20% of children hospitalized with CAP may need intensive care, which can result in significant morbidity. Given this burden of disease, it is critical that CAP is managed appropriately. Specific therapy for CAP is dependent on microbiologic aetiology, as bacterial disease will improve with antibiotic treatment.
CONDITIONS
Official Title
PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 6 months to 18 years diagnosed with community-acquired pneumonia (CAP) in the Emergency Department
- Diagnosed with non-severe CAP and well enough to be discharged home
- Fever present on exam or by history
- At least one of the following: tachypnoea by age-specific rates, cough, increased work of breathing, or lung exam findings consistent with CAP
You will not qualify if you...
- Diagnosis of cystic fibrosis
- Anatomic lung disease or bronchiectasis
- Chronic lung disease requiring home oxygen or ventilation
- Congenital heart disease needing specific medical treatment or exercise restrictions
- History of repeated aspiration or velopharyngeal incompetence
- Malignancy
- Immunodeficiency (primary, acquired, or iatrogenic)
- Pneumonia diagnosed within the past month
- Lung abscess within the past 6 months
- Persistent fever after 4 days of certain antibiotics (amoxicillin, cefprozil, cefuroxime, levofloxacin, moxifloxacin, doxycycline)
- Prior participation in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Alberta Children's hospital
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
2
Stollery Children's Hospital
Edmonton, Alberta, Canada, T6G 2B7
Not Yet Recruiting
3
BC Children's Hospital
Vancouver, British Columbia, Canada, V6H 3N1
Not Yet Recruiting
4
McMaster Children's Hospital
Hamilton, Ontario, Canada, L8S 4K1
Not Yet Recruiting
5
Children's Hospital of Eastern Ontario (CHEO)
Ottawa, Ontario, Canada, K1H 8M8
Actively Recruiting
6
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1E8
Not Yet Recruiting
Research Team
J
Jeffrey Pernica, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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