Evaluating Low-Intensity Focused Ultrasound for Recovery in Adults with Disorders of Consciousness After Severe Brain Injury

What this Trial Is About

This research aims to develop a treatment to improve recovery in adults who survive severe brain injury but have disorders of consciousness DoC. The study evaluates responses to low-intensity focused ultrasound LIFUP in patients with DoC, exploring both behavioral and brain activity changes. It also seeks to understand ethical views from patient representatives regarding neuromodulation therapies like LIFUP. Participants will receive LIFUP to the brain as the main intervention. They will also undergo advanced MRI scans and EEG monitoring to assess brain structure and function. Family members or surrogate decision-makers, as well as recovered patients, will participate in interviews to provide insights into ethical considerations surrounding this treatment approach. During the study, participants will be assessed for neurobehavioral changes using tools like the Coma Recovery Scale-Revised and Disability Rating Scale over the first three days. EEG responses will be recorded, and MRI scans will be used to identify brain patterns that may predict treatment response. Interviews with surrogates and recovered patients will also be conducted. The total participation extends through these initial assessments, contributing to treatment development and ethical understanding.

Promoting Recovery After Brain Injury Using Focused Ultrasound