Actively Recruiting
Promoting Recovery After Brain Injury Using Focused Ultrasound
Led by Massachusetts General Hospital · Updated on 2026-02-18
36
Participants Needed
2
Research Sites
174 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
CONDITIONS
Official Title
Promoting Recovery After Brain Injury Using Focused Ultrasound
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of disorder of consciousness following brain injury based on international guidelines
- Age 18 years or older
- Legally authorized representative (surrogate) available to provide consent
You will not qualify if you...
- History of neurological disorder other than the brain injury
- Metal implants or other conditions preventing MRI
- Continuous spontaneous movement preventing safe MRI
- Participation in another therapeutic study
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Massachusetts General Hospital (The General Hospital Corp.)
Boston, Massachusetts, United States, 02114
Actively Recruiting
2
Spaulding Rehabilitation Hospital Corporation, Inc.
Cambridge, Massachusetts, United States, 02138
Actively Recruiting
Research Team
M
Michael Young, MD, MPhil
CONTACT
J
Jason Lew, DO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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