Actively Recruiting
Promoting Recovery After STroke With Amantadine
Led by University of Pennsylvania · Updated on 2026-03-30
60
Participants Needed
1
Research Sites
334 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. Patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. At various time points patients will be examined and fill out questionnaires to determine level of stroke recovery.
CONDITIONS
Official Title
Promoting Recovery After STroke With Amantadine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years, male or female
- Modified Rankin Score (mRS) of 2 or less before stroke
- Diagnosed ischemic or hemorrhagic stroke confirmed by neurologist or brain imaging
- Stroke occurred 24 hours to 3 weeks before enrollment
- National Institute of Health Stroke Scale (NIHSS) score between 3 and 15
- Creatinine clearance of 60 mL/min or higher
- Passed a swallow evaluation before drug administration
- Candidate for acute rehabilitation or Homeward Stroke Program
- Able to participate in study tests
You will not qualify if you...
- Any level of receptive aphasia
- Moderate or severe expressive aphasia
- Currently pregnant or planning pregnancy
- Currently breastfeeding
- Primary subarachnoid hemorrhage on brain imaging
- Diagnosis of dementia or mild cognitive impairment before stroke
- Prior limb amputation
- Taking primary anticholinergic medication
- Enrolled in another investigational drug or procedure trial
- Active cancer treatment
- Previous stroke with lasting impairment
- Current or past neuroleptic medication use
- History of suicidality or psychosis
- History of seizures
- Previous treatment with amantadine
- Parkinson's disease diagnosis
- Allergy to amantadine
- Elevated liver function tests above normal limits
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
A
Aaron Rothstein, M.D
CONTACT
N
Nichole Gallatti, M.S.Ed.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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