Actively Recruiting
Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
Led by Ayal A. Aizer, MD · Updated on 2026-03-19
150
Participants Needed
1
Research Sites
214 weeks
Total Duration
On this page
Sponsors
A
Ayal A. Aizer, MD
Lead Sponsor
D
Dana-Farber Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized trial for patients with brain metastases in the primary motor cortex who have not had seizures to receive either the prophylactic anti-seizure medication levetiracetam (also known by its trade name Keppra) or proceed with standard of care management, which does not currently include prophylactic levetiracetam. Patients who enroll to this trial will be randomized to receive prophylactic levetiracetam or not receive prophylactic levetiracetam.
CONDITIONS
Official Title
Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy-proven solid tumor with at least one brain metastasis in the primary motor cortex measuring 0.5 cm or larger
- Age 18 years or older
- Karnofsky performance status of at least 60
- Estimated survival of at least 3 to 6 months as determined by clinician
- Ability and willingness to provide informed consent
You will not qualify if you...
- History of prior seizures
- Allergy to levetiracetam
- Taking anti-seizure medications at clinically relevant doses for non-seizure reasons
- Unable to tolerate brain MRI
- Unable to receive gadolinium contrast for MRI
- End stage renal disease
- Presence of widespread leptomeningeal disease
- Pregnant women
- Breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
A
Ayal A Aizer, MD, MHS
CONTACT
I
Ivy B Ricca, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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