Actively Recruiting
Prophylactic Antibiotics in Cystectomy With Diversion
Led by University of Minnesota · Updated on 2025-11-17
120
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.
CONDITIONS
Official Title
Prophylactic Antibiotics in Cystectomy With Diversion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
- 18 years of age or older
You will not qualify if you...
- Currently receiving antimicrobials for active infection
- Poor renal function with GFR < 30 ml/min
- Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)
- Pregnancy
- Unable to provide Informed consent
- Prior pelvic radiation
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
J
Judith Graziano
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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