Actively Recruiting
Prophylactic CD45RA-depleted DLI After Haploidentical Transplantation/RIC
Led by University Hospital, Geneva · Updated on 2025-02-13
12
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess safety of prophylactic escaladed dose of T naïve depleted (CD45RA depleted donor lymphocyte infusion, in patients with malignant hemopathie who received an allogeneic stem cell transplant from an haplo-identical donor, after a reduced intensity conditionning regiment.
CONDITIONS
Official Title
Prophylactic CD45RA-depleted DLI After Haploidentical Transplantation/RIC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who received a stem cell graft from a haploidentical donor after reduced intensity conditioning for hematologic malignancies
- Written informed consent of patient and donor obtained
You will not qualify if you...
- Taking Prednisone (or equivalent steroid)
- Taking Mycophenolate Mofetil
- Taking Cyclosporine or Tacrolimus at therapeutic blood levels
- Progressive hematologic malignancy before transplant
- Having a second allogeneic transplant
- Acute graft-versus-host disease grade 2 or higher
- Moderate or severe chronic graft-versus-host disease
- Hematologic or molecular relapse requiring chemotherapy or unmanipulated DLI
- Donor with abnormal CD45RA expression due to genetic polymorphism
- Participation in another interventional clinical trial within 30 days prior
- Pregnant or nursing women
- Sexually active patients unwilling to use effective contraception during study and 2 months after last infusion
- Inability to follow study procedures due to language, psychological, or cognitive issues
AI-Screening
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Trial Site Locations
Total: 1 location
1
HUG
Geneva, Canton of Geneva, Switzerland, 1205
Actively Recruiting
Research Team
A
Anne-Claire Mamez
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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