Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID06762561

Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair: a Retrospective Study

Led by Hôpital Fribourgeois · Updated on 2025-06-03

20

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to evaluate whether reinforcing the abdominal wall with a mesh during closure after open abdominal aortic aneurysm (AAA) repair can prevent incisional hernias (IH). The study is retrospective and observational, focusing on patients who had this mesh reinforcement technique between 2019 and 2024. Researchers want to understand if mesh use reduces hernia rates and how often related postoperative complications occur compared to cases without mesh reported in the literature. The treatment studied is prophylactic retromuscular mesh reinforcement, where a mesh is placed behind the rectus abdominis muscles during abdominal closure to strengthen the wall and reduce hernia risk. This is done by carefully dissecting muscle layers and placing a self-gripping polyester or composite mesh extending beyond the midline without tension. The mesh is secured and the abdominal layers are sutured closed. The study looks at patients treated at one hospital over several years with this technique. Participants underwent clinical follow-ups and abdominal ultrasounds to detect incisional hernias. They also completed quality-of-life questionnaires including EQ-5D and PROMIS. The primary outcome measured is the rate of incisional hernias within a specific timeframe (January to April 2025). Secondary outcomes include rates of complications such as fascial dehiscence, seromas, surgical site infections, hematomas, and operative time. The study relies on reviewing medical records and follow-up data from at least one year after surgery.

CONDITIONS

Brief Title

Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients (≥18 years old) who underwent open abdominal aortic aneurysm (AAA) repair with prophylactic retromuscular mesh reinforcement between January 2019 and January 2024
  • Availability of complete medical records, including preoperative history, surgical details, and postoperative follow-up data
  • Attendance at a clinical follow-up examination at least one year after the procedure
  • General informed consent signed for the use of medical data for research purposes
Not Eligible

You will not qualify if you...

  • Patients with incomplete or missing medical records, including preoperative, intraoperative, or follow-up data
  • Patients who required a re-laparotomy involving incision or suture of the prophylactic mesh and subsequently developed an incisional hernia
  • Patients who did not attend the required clinical follow-up examination at least one year postoperatively

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Surgery and immediate recovery period

Participants undergo open abdominal aortic aneurysm repair with prophylactic retromuscular mesh reinforcement to reduce the risk of incisional hernias.

1 surgical procedure and hospitalization period

Post-operative Follow-up

Duration - At least 1 year after surgery

Participants attend clinical follow-up examinations to monitor surgical outcomes and potential complications such as hernias, infections, or hematomas.

At least 1 follow-up visit at 1 year post-operation

Trial Site Locations

Total: 1 location

1

HFR Hopitaux Fribourgeois

Villars-sur-Glâne, Switzerland

Actively Recruiting

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Research Team

R

Raffaella Sguinzi, PhD

M

Melissa Lagger

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Updated Guideline on Abdominal Wall Closure from the European and American Hernia Societies: Transferring Recommendations to Clinical Practice for Vascular Surgeons.

George A Antoniou, Filip E Muysoms, Eva B Deerenberg

https://pubmed.ncbi.nlm.nih.gov/36804613

Abdominal aortic aneurysm and abdominal wall hernia as manifestations of a connective tissue disorder.

George A Antoniou, George S Georgiadis, Stavros A Antoniou...

https://pubmed.ncbi.nlm.nih.gov/21820838

Development and validation of a risk stratification score for ventral incisional hernia after abdominal surgery: hernia expectation rates in intra-abdominal surgery (the HERNIA Project).

Christopher J Goodenough, Tien C Ko, Lillian S Kao...

https://pubmed.ncbi.nlm.nih.gov/25690673

Early use of mammalian target of rapamycin inhibitors is an independent risk factor for incisional hernia development after liver transplantation.

Roberto Montalti, Antonio Mimmo, Gianluca Rompianesi...

https://pubmed.ncbi.nlm.nih.gov/21987434

Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies.

Eva B Deerenberg, Nadia A Henriksen, George A Antoniou...

https://pubmed.ncbi.nlm.nih.gov/36026550

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms.

Anders Wanhainen, Isabelle Van Herzeele, Frederico Bastos Goncalves...

https://pubmed.ncbi.nlm.nih.gov/38307694