Actively Recruiting
Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass
Led by Ain Shams University · Updated on 2025-04-09
170
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the planned study is to assess the prophylactic effect of intraoperative administration of a single dose of methylprednisolone 2 (mg/kg) in decreasing the incidence of postoperative acute kidney injury after cardiac surgeries with cardiopulmonary bypass.
CONDITIONS
Official Title
Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Both males and females
- Patients with an American Society of Anesthesiologists (ASA) score of III or IV
- Scheduled for elective cardiac surgery requiring cardiopulmonary bypass, such as coronary artery bypass grafting, valve repair or replacement, or combined procedures
You will not qualify if you...
- Declining to give written informed consent
- Allergy to medications used in the study
- Diabetes with HbA1C greater than 6.5
- Moderate to severe liver disease (Child B or C)
- Liver dysfunction with INR above 1.5 or serum albumin below 2.9 g%
- Kidney dysfunction with serum creatinine above 1.3 mg/dl or GFR below 80 ml/min/1.73m2
- Recent acute kidney injury
- Urgent cardiac surgery
- Cardiac surgery with deep hypothermic total circulatory arrest
- Planned off-pump cardiac procedures
- Cardiac surgery exceeding 45 minutes of aortic cross clamp time
- Need for high-dose inotropes or vasopressors during or after surgery
- Delay in extubation over 6 hours after surgery
- Postoperative complications such as septic shock or bleeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ain Shams University
Cairo, Abbasia, Egypt, 00202
Actively Recruiting
Research Team
A
Abdelrahman Atef Atef, M.B., B.Ch Faculty of Medicine
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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