Actively Recruiting
Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
Led by St. Joseph's Hospital and Medical Center, Phoenix · Updated on 2018-08-15
116
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
S
St. Joseph's Hospital and Medical Center, Phoenix
Lead Sponsor
T
Thomas Jefferson University
Collaborating Sponsor
AI-Summary
What this Trial Is About
To find out whether oral antibiotics given after transsphenoidal endoscopic surgery for pituitary adenoma improves sinus and nasal symptoms, reduces the incidence of infection (sinusitis), and helps mucosal healing in the nasal passages.
CONDITIONS
Official Title
Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient undergoing endoscopic surgery for resection of pituitary tumors for nonfunctioning adenoma, acromegaly, or prolactinoma
- Adults over 18 and under 85 years of age
- English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales
- Free of any physical, mental, or medical condition which, in the opinion of the investigator, makes study participation inadvisable
You will not qualify if you...
- Anaphylaxis or intolerance to the study drugs
- Cirrhosis or hepatitis
- Any solid organ or bone marrow transplant or immunocompromised status
- Renal failure requiring dialysis
- Unwilling or unable to sign informed consent
- Pregnancy
- Incarcerated patients
- Diagnosis of Cushing's disease
- Presence of Rathke's Cleft cyst or pituitary cyst
- History of chronic sinusitis
- Anticipated use of nasal splints or nasal septal flap
- Active sinusitis
- Nasal polyps
- Previous sinus surgery
- Use of antibiotics for another infection
- Immunodeficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Barrow Brain and Spine
Phoenix, Arizona, United States, 85013
Actively Recruiting
Research Team
H
Heidi Jahnke, RN, MSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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