Polyp Prophylactic Properties of Polyacetylenes in Patients With Previous Polypectomy

What this Trial Is About

Researchers are evaluating whether drinking carrot juice rich in polyacetylenes can help prevent the return and growth of high-risk colorectal polyps in patients who have undergone adenoma resection. This prospective, randomized, double-blinded trial takes place across multiple centers in Denmark and Sweden, aiming to see if the active compounds falcarinol and falcarindiol reduce neoplastic transformation in these patients. Participants are randomly assigned to one of two groups: one drinks 100 ml of active carrot juice daily, and the other drinks 100 ml of placebo juice daily, both for one year. The juices are carefully produced and taste-matched to keep the study blinded. Patients receive juice supplies and keep a diary or calendar to track consumption. A follow-up colonoscopy is scheduled after one year, with an additional six-month colonoscopy for those with piecemeal resections. During the study, patients attend visits every two months to collect juice and questionnaires and discuss adherence with a nurse. Researchers monitor compliance by measuring juice consumption and analyze outcomes such as the number and size of recurrent polyps, polyp dysplasia levels, side effects, and treatment acceptability. The primary outcome is the number and size of recurrent polyps found at the one-year colonoscopy.

Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps