Actively Recruiting
Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps
Led by Odense University Hospital · Updated on 2025-11-20
400
Participants Needed
1
Research Sites
179 weeks
Total Duration
On this page
Sponsors
O
Odense University Hospital
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.
CONDITIONS
Official Title
Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Had any type of resection for adenomas larger than 20 mm or endoscopically resected T1 cancers
- Agree to follow the treatment and follow-up program
- Able to understand and follow study instructions
You will not qualify if you...
- High-risk group patients with more than 4 small polyps
- Pregnant individuals
- Known allergies relevant to the study
- Chronic use of COX inhibitors (e.g., Aspirin, Ibuprofen) or immunosuppressive agents
- Patients undergoing treatment for other cancers (chemotherapy, radiotherapy, immunotherapy)
- Severe heart failure (NYHA class III-IV)
- Diagnosed with Lynch syndrome
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Surgery, Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
Research Team
G
Gunnar Baatrup, Professor
CONTACT
A
Alexandra D Agache, Postdoc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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