Actively Recruiting
Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC
Led by Jiangxi Provincial Cancer Hospital · Updated on 2025-04-10
474
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter, non-inferiority, open-label, randomized controlled Phase III clinical trial. It aims to compare the efficacy of modified delineation radiotherapy (experimental group) versus standard delineation radiotherapy (control group) in the prophylactic irradiation of neck lymphatic drainage areas III/IVa in nasopharyngeal carcinoma. The study evaluates the incidence of primary hypothyroidism, quality of life, and adverse events between the two groups.
CONDITIONS
Official Title
Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 70 years
- Pathologically confirmed nasopharyngeal carcinoma
- No positive lymph nodes in unilateral or bilateral neck regions III and IVa
- Clinical stage I to IVa without distant metastasis (AJCC/UICC 8th edition)
- Normal thyroid function
- ECOG performance status of 0 to 1
- Treatment-nafve patients with no prior antitumor therapy
- No contraindications to radiotherapy or chemotherapy
- Adequate organ function meeting specified blood counts and biochemical criteria
- Voluntarily agree to participate and comply with study follow-up
You will not qualify if you...
- History of other malignant tumors (except basal cell carcinoma/squamous cell carcinoma of skin or cervical carcinoma in situ)
- History of radiotherapy (except outside planned target area for certain conditions)
- History of neck surgery
- Severe comorbidities affecting safety or compliance (unstable heart disease, kidney disease, chronic hepatitis, poorly controlled diabetes, psychiatric disorders)
- History of hyperthyroidism, hypothyroidism, or immune-related thyroid disorders
- Family or social factors that may threaten safety, compliance, or data collection according to investigator judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jiangxi Cancer Hospital
Nanchang, Jiangxi, China, 330029
Actively Recruiting
Research Team
X
Xiaochang Gong, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here