Actively Recruiting
Propofol Infusion and PONV in Cardiac Surgery
Led by Istanbul University - Cerrahpasa · Updated on 2026-02-04
60
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this observational cohort study is to evaluate the effect of high-dose versus low-dose propofol infusion on the incidence of postoperative nausea and vomiting (PONV) in patients undergoing coronary artery bypass grafting (CABG). The study also seeks to assess the predictive performance of the Apfel and Koivuranta risk scores for PONV in the cardiac surgery population. The primary objective of this study is to determine the impact of routinely administered high-dose propofol on the incidence and severity of PONV in CABG patients. The secondary objective is to evaluate the need for antiemetic therapy during the intensive care unit stay. The investigators will compare patients receiving high-dose propofol with those receiving low-dose propofol to determine whether the antiemetic effect of propofol is dose-dependent. Participants will be asked to: Allow PONV assessments to be performed during the first 24 hours postoperatively, Provide permission for the collection of clinical data (including demographic characteristics, risk scores, opioid consumption, etc.) for research purposes.
CONDITIONS
Official Title
Propofol Infusion and PONV in Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 18 years
- ASA physical status III
- Elective coronary artery bypass grafting (CABG)
- Surgery performed at Istanbul University-Cerrahpa5fa, Cardiology Institute between November 2025 and March 2026
You will not qualify if you...
- Gastrointestinal or central nervous system disorders within the past 3 months
- Cochlear disorders associated with nausea and vomiting
- Chronic opioid use
- Advanced hepatic or renal disease
- Alcohol or substance abuse
- Left ventricular ejection fraction < 40%
- Inability to be weaned from mechanical ventilation within 12 hours postoperatively
- Postoperative morphine administration in the intensive care unit
- Combined cardiac procedures (e.g., valve surgery)
- Off-pump surgery
- Emergency surgery
- Reoperation due to bleeding or other complications
- Refusal to participate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Yasemin Ozsahin
Istanbul, Outside of the US, Turkey (Türkiye), 34000
Actively Recruiting
Research Team
Y
Yasemin Ozsahin
CONTACT
K
Kerem Erkalp
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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