Actively Recruiting
Propranolol for Misophonia
Led by Bloom Mental Health, LLC · Updated on 2025-12-09
20
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia. The secondary goals of this study are: 1. Determine potential predictors of response to propranolol treatment, including demographic factors, baseline symptom severity, psychometric instrument item responses, and physiological characteristics. 2. Evaluate the safety and tolerability of propranolol in individuals with misophonia.
CONDITIONS
Official Title
Propranolol for Misophonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65.
- Able to complete study visits in Littleton, CO.
- Able to give informed consent.
- Reports clinically significant misophonia symptoms meeting minimum severity on the standardized Misophonia Trigger Screening Questions.
- Scores at least moderate ("2") or higher on questions 2 and 3 of the Amsterdam Misophonia Scale (A-MISO-S) at screening.
- Able to communicate misophonic distress in writing and participate in the outpatient clinical setting.
- Willing to follow study clinician advice and seek additional care if advised.
- English fluency.
You will not qualify if you...
- Current use of scheduled propranolol for any condition.
- Contraindications to propranolol including cardiogenic shock, sinus bradycardia (<50 bpm), greater than first degree heart block, blood pressure below 90/60, asthma or bronchial asthma requiring treatment or with clinical concerns in the past 5 years.
- Other heart conditions requiring ongoing treatment.
- Relative contraindications including active anorexia, purging, or underweight (BMI <18.5).
- Active drug or alcohol use within 48 hours prior to participation or active withdrawals.
- History of untreated diabetes or other endocrine disorders harmful with propranolol.
- History of cardiovascular disease, stroke, or symptomatic blood disorders like anemia.
- History of severe physical or neurological conditions affecting study participation.
- Liver or kidney disease affected by the study drug.
- Conditions possibly causing adverse propranolol reactions such as Raynaud disease, pheochromocytoma, psoriasis, untreated thyroid disease, unexplained dizziness, oxygen level below 91%, respirations below 12 or above 20.
- Use of medications interfering with propranolol effects as determined by the study clinician.
- Allergy or sensitivity to propranolol, placebo, or capsule ingredients.
- Pregnant or nursing.
- Active psychosis, suicidal or self-harming thoughts, bipolar mania, panic attacks, traumatic dissociation, PTSD flashbacks, or psychiatric hospitalization in 30 days prior to enrollment.
- History of misophonia-triggered reactions posing significant health or safety risks within the past year.
- Misophonia symptoms better explained by other conditions such as hyperacusis or phonophobia.
- Severe hearing impairment interfering with hearing misophonia triggers on video.
- Participants triggered by sounds of water running or car alarms (control videos).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bloom Mental Health
Littleton, Colorado, United States, 80120
Actively Recruiting
Research Team
B
Bloom Mental Health Clinic
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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