Actively Recruiting
Propranolol in Primary Progressive Aphasia
Led by University of Missouri-Columbia · Updated on 2025-03-28
30
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
CONDITIONS
Official Title
Propranolol in Primary Progressive Aphasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 and older
- Diagnosis of Primary Progressive Aphasia
- Native English speaker
You will not qualify if you...
- Unable to provide consent
- Taking alpha 2 agonists (clonidine and guanfacine)
- Other major psychological or neurological diagnoses
- Major head trauma contributing to the condition
- Allergic reaction to adhesives
- Uncorrected vision or hearing impairments
- Diabetes
- Reactive airway disease
- Untreated hypothyroidism
- Bradyarrhythmia
- Unexplained syncope
- Pregnancy (assessed verbally on MRI days)
- Use of drugs interacting with propranolol, such as alpha 2 agonists
- Claustrophobia or contraindications to MRI including inner ear implants, aneurysm or surgical clips, metal in eye, pacemaker, or unverified implanted devices
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri-Columbia
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
D
David Beversdorf, MD
CONTACT
J
Jessica Call
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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