Actively Recruiting
PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification
Led by M.D. Anderson Cancer Center · Updated on 2025-08-15
7200
Participants Needed
1
Research Sites
975 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this Project, we will use therapeutic target -focused (TTF) profiling, genome-wide mRNA profiling and assessments of tumor phosphopeptides and DNA that are shed into the blood stream to define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, and to metastatic patterns at relapse. We will examine how the presence of factors that drive cell growth, antagonize apoptosis, or confer resistance in other ways may counter the effect of systemic therapies and/or promote rapid tumor recurrence. In this way, we will identify new, previously unappreciated potential therapeutic targets while also identifying which targets are most likely to increase resistance to therapy and worsen prognosis.
CONDITIONS
Official Title
PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with stage I to IIIA non-small cell lung cancer (NSCLC) who are undergoing surgical removal of the tumor with or without chemotherapy before surgery
- Availability of demographic information, smoking history, clinical data before surgery, and follow-up data including additional therapy and relapse treatment
- Includes patients with the three main NSCLC types: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Caner Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
L
Luisa M Solis Soto, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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